Metabolic Engineering is a specialized skill that involves the manipulation of an organism's metabolic pathways through genetic and biochemical techniques, leading to the production of desired compounds or increased metabolic efficiency. This technique is commonly used in biotechnology, pharmaceuticals, agriculture, and environmental science for applications such as the production of drugs or biofuels, or the development of disease-resistant crops. Successful metabolic engineering requires a thorough understanding of the biological system being manipulated, as well as advanced skills in genetics, biotechnology, and biochemical engineering.