Derivatization is a chemical process where the chemical structure of a compound is modified by adding a functional group to enhance its detection or separation capabilities. It is a specialized skill that requires knowledge of chemistry and analytical instrumentation. Derivatization can be used in various fields such as pharmaceuticals, food analysis, and environmental monitoring. The process aims to improve the accuracy, sensitivity, and selectivity of the analysis, by making the analytes more compatible with the analytical technique used. After derivatization, the modified analyte can be easily detected and analyzed using different techniques such as chromatography, mass spectrometry, and spectroscopy.